NSF Engines: Piedmont Triad Regenerative Medicine Engine

Founders' Journey Speaker

A.J. Mellott, PhD

A.J. Mellott, PhD

Co-Founder and CEO

Dr. A.J. Mellott’s journey in bioengineering is marked by a relentless pursuit of innovation and a passion for advancing medical research and therapy development. Earning his Ph.D. in Bioengineering from the University of Kansas in 2014, Dr. Mellott’s pioneering research on tissue engineering strategies for hearing restoration earned him his first patent and set the stage for a career defined by groundbreaking discoveries.

His postdoctoral work delved into the transformative power of biomaterials for manipulating the extracellular environment to influence cell behavior within the central nervous system. These foundational insights led to the creation of Ronawk’s revolutionary Bio-Block® platform technology, a game-changer in the field of biotechnology.

In 2015, Dr. Mellott joined the University of Kansas Medical Center’s Department of Plastic Surgery, where he established the Repair, Reconstruction, and Regeneration (R3) Lab. His research team’s innovative approach to evaluating wound dressings and therapies resulted in multiple patents and publications, providing a wealth of knowledge on cellular behavior in diverse environments.

Recognizing the need for accelerated development and translation of next-generation therapies, Dr. Mellott co-founded Ronawk Inc. in 2019. Ronawk’s Bio-Block technology, consisting of interconnecting porous hydrogel blocks, overcomes many limitations of current cell and biologics manufacturing technologies. By creating a more in vivo-like environment, Bio-Blocks promote cellular interactions and reduce production costs by 90% or more. These plug and play modular, scalable, and dynamic blocks enable the mass production of cells, cellular biologics, and tissues tailored to specific populations.

In 2020, Dr. Mellott transitioned to the full-time role of CEO to steer Ronawk’s growth and the further development of the Bio-Block Universe. Under his visionary leadership, Ronawk has grown to a team of approximately 15 full-time employees, raised over $10 million in equity funding, and secured $2.1 million in grant funding. The Company continues to develop its cutting-edge tissue-mimetic technologies for organ engineering, and tissue regeneration, disease modeling, drug discovery and personalized medicine.

Driven by an entrepreneurial spirit and deep scientific expertise, Dr. Mellott is on a mission to revolutionize the production of biological raw materials, making it more reflective of natural cell growth and responsive to the urgent needs of medical research and therapy development. His dynamic leadership continues to inspire innovation, advancing the boundaries of life sciences and delivering tangible outcomes that accelerate research, cost-effective therapy development, and faster delivery of new treatments to patients in need.