NSF Engines: Piedmont Triad Regenerative Medicine Engine

In-Space Biomanufacturing

What is In-Space Biomanufacturing?

In-Space biomanufacturing refers to the next-generation approach to developing products that can’t be produced here on Earth.  Leveraging the changes in cell biology and cell-matrix interaction that occur in the microgravity environment of low-Earth orbit provides an opportunity to overcome some of the most significant manufacturing challenges that are faced in the regenerative medicine industry today. This unique approach provides not only next-level innovation, but the opportunity for an entire new industry – space – to join our region.

Innovations in Progress: 

  • Development of in-space biomanufacturing methods for regenerative medicine products.

  • Creation of infrastructure and logistics to support next-generation approaches for commercialization of regenerative medicine products in low-Earth orbit.

Key Milestones: 

  • Parameter setting missions to the International Space Station (ISS) for in-space biomanufacturing of thick liver tissue constructs as a bridge to transplantation working in partnership with NASA In Space Production Applications (InSPA).

  • Missions to the ISS for the development of AI-driven Patient Tumor Organoid models that stand to accelerate new approaches for chemotherapy working in partnership with the Center for the Advancement of Science in Space (CASIS), managers of the ISS National Laboratory Igniting Innovation program.

Impact

In-Space Biomanufacturing provides a next-generation approach to innovation for regenerative medicine technologies.  Removing gravity provides unique opportunities and innovative approaches that stand to accelerate the field of regenerative medicine by taking it literally to new heights.